Glucocorticoids Amplify Dibutyl Phthalate-Induced Disruption of Testosterone Production and Male Reproductive Development
نویسندگان
چکیده
منابع مشابه
Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes.
Exposure to plasticizers di(n-butyl) phthalate (DBP) and diethylhexyl phthalate (DEHP) during sexual differentiation causes male reproductive tract malformations in rats and rabbits. In the fetal male rat, these two phthalate esters decrease testosterone (T) production and insulin-like peptide 3 (insl3) gene expression, a hormone critical for gubernacular ligament development. We hypothesized t...
متن کاملDevelopment of an analytical method for dibutyl phthalate determination using Surrogate analyte approach
Dibutyl phthalate (DBP) is a phthalic acid ester and is widely used in polymeric products to make them more flexible. DBP is found in almost every plastic material and is believed to be persistent in the environment. Various analytical methods have been used to measure DBP in different matrices. Considering the ubiquitous nature of DBP, the most important challenge in DBP analyses is the contam...
متن کاملDevelopment of an analytical method for dibutyl phthalate determination using Surrogate analyte approach
Dibutyl phthalate (DBP) is a phthalic acid ester and is widely used in polymeric products to make them more flexible. DBP is found in almost every plastic material and is believed to be persistent in the environment. Various analytical methods have been used to measure DBP in different matrices. Considering the ubiquitous nature of DBP, the most important challenge in DBP analyses is the contam...
متن کاملDifferent ontogenetic patterns of testosterone production reflect divergent male reproductive strategies in chimpanzees and bonobos.
Male reproductive effort is often strongly related to levels of the steroid hormone testosterone. However, little research has examined whether levels of testosterone throughout development might be tied to individual or species differences in the reproductive strategies pursued by adult males. Here, we tested the hypothesis that inter-specific differences in male reproductive strategy are asso...
متن کاملPeroxisome proliferator-activated receptors: mediators of phthalate ester-induced effects in the male reproductive tract?
Many phthalate ester plasticizers are classified as peroxisome proliferators (PP), a large group of industrial and pharmaceutical chemicals. Like PP, exposure to some phthalates increases hepatocyte peroxisome and cellular proliferation, as well as the incidence of hepatocellular adenomas in mice and rats. Most effects of PP are mediated by three nuclear receptors called peroxisome proliferator...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2009
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2009-0700